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pentobarbital will lessen the level or effect of parecoxib by influencing hepatic enzyme CYP2C9/ten metabolism. Use Caution/Keep track of.Watch Closely (one)pentobarbital will lower the level or effect of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Lack of, or reduced reaction to tofacitinib coul